Objectives To explain the technical principles of and differences between commercially
available iterative reconstruction (IR) algorithms for computed tomography (CT) in non-…

Background— Hemodynamically significant coronary artery disease is an important indication
for revascularization. Stress myocardial perfusion imaging is a noninvasive alternative to …

Objectives To present the results of a systematic literature search aimed at determining to
what extent the radiation dose can be reduced with iterative reconstruction (IR) for …

Background There are limited data from randomized trials regarding whether volume-based,
low-dose computed tomographic (CT) screening can reduce lung-cancer mortality among …

Using genome-wide data from 253,288 individuals, we identified 697 variants at genome-wide
significance that together explained one-fifth of the heritability for adult height. By testing …

Objective To use the rs1229984 variant in the alcohol dehydrogenase 1B gene (ADH1B) as
an instrument to investigate the causal role of alcohol in cardiovascular disease. Design …

Background Statins increase the risk of new-onset type 2 diabetes mellitus. We aimed to
assess whether this increase in risk is a consequence of inhibition of 3-hydroxy-3-methylglutaryl…

Background The main challenge in CT screening for lung cancer is the high prevalence of
pulmonary nodules and the relatively low incidence of lung cancer. Management protocols …

Chronic obstructive pulmonary disease is characterized by destruction of the lung parenchyma
and/or small airway narrowing. To determine whether the dimensions of relatively large …

Background Low-dose CT screening is recommended for individuals at high risk of developing
lung cancer. However, CT screening does not detect all lung cancers: some might be …