The Article in Brief

Effect of Psyllium Fiber Supplementation on C-Reactive Protein: The Trial to Reduce Inflammatory Markers (TRIM)

Dana E. King, MD , and colleagues

Background High levels of C-reactive protein (a protein in the blood that indicates inflammation) have been associated with increased risk of cardiovascular disease, whereas diets high in fiber have been shown to lower the risk of cardiovascular disease. This study examines whether supplementing the diet with psyllium, a form of fiber, affects levels of C-reactive protein and other indicators of inflammation in overweight or obese adults.

What This Study Found In overweight or obese adults, taking daily psyllium fiber supplements does not appear to significantly lower the levels of inflammation that play a role in cardiovascular risk. These findings contrast with previous research suggesting that dietary fiber is associated with levels of C-reactive protein.

Implications

• A diet naturally high in fiber is important; however, taking a psyllium supplement may not be an effective way to reduce inflammation and risk of cardiovascular disease.
• The authors call for further research with other types of fiber or with combinations of nutrients.